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ea0099rc1.2 | Rapid Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Endometrial transcriptome alterations following short-term liraglutide treatment in infertile women with polycystic ovary syndrome and obesity

Jensterle Mojca , Salamun Vesna , Vrtacnik Bokal Eda , Lovrecic Luca , Maver Ales , Peterlin Borut , Herman Rok , Janez Andrej

Objective: Obesity and polycystic ovary syndrome (PCOS) affect endomertial receptivity and may cause implantation failure, defective placentation, and pregnancy loss. Glucagon-like peptide-1 (GLP-1) receptor agonist (RA) improved the endometrial function in animal models, presumably by anti-inflammatory action and reduction of endometrial fibrosis. The impact of GLP-1RA on human endometrioum has not yet been investigated.Aim: We compared endometrial tran...

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Endometrial transcriptome alterations following short-term liraglutide treatment in infertile women with polycystic ovary syndrome and obesity

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